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. 2021 Aug 27;11(5):1707–1715. doi: 10.1007/s13555-021-00587-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 1 — Flowchart of study cohort selection. Patients were selected from the MarketScan^® database from 2007 to 2014 as part of the AD cohort if they had at least two AD claims, or as part of the non-AD cohort if they had no AD claims. Patients with AD were matched with non-AD controls by age, sex, index date, and follow-up period. Patients with a known history of CVD or MACE were excluded from the study. AD atopic dermatitis, CVD cardiovascular disease, MACE major adverse cardiovascular events