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. 2021 Sep 30;11:19520. doi: 10.1038/s41598-021-98852-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Vascular organization of intact caudal fin vs. early regeneration. Organization of tissue compartments in the intact caudal fin (a) versus the regenerating fin (b), at 7dpa. a/a’ display smooth and hierarchically well-organized blood vessels (green - reporter transgenic zebrafish line) in which intraray segments do not contain any vessels (asterisk) and capillary sprouts are not detectible (a’). (b/b’) display dense, well-interconnected capillary meshwork. The intraray region (purple asterisks) contains bridging vessels and at the expanding vascular front multiple sprouts (b’, white arrows) and migrating - endothelial cells (purple arrows). Images are acquired by fluorescent reflected light microscope.