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. 2021 Sep 30;11:19520. doi: 10.1038/s41598-021-98852-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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In vitro ECs migration on collagen I and collagen IV substrates. The blue region denotes the scratch wound mask over time (0 h, 4 h, 8 h, and 12 h). ECs migrate into the wound area on non-coated (a), collagen I-coated (b) and collagen IV-coated wells (c). The red area depicts the wound closure by EC expansion over time. The most effective and fast EC migration is observed with the collagen I substrate, followed by collagen IV and lastly, the least efficient, non-coated wells at 0, 4, 8, and 12 h (a–c’’’; d, e, and f). Relative wound density (d), wound confluence (e) and wound width (f) has been quantified. Cells in the wound area are the most confluent in collagen I-coated wells, followed by collagen IV and non-coated wells (e). Blue dashed line - collagen I, green dashed line - collagen IV, purple dashed line - no collagen, black dashed line - time points (4 h, 8 h, 12 h).