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. 2021 Sep 30;4:1143. doi: 10.1038/s42003-021-02672-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Hierarchical clustering analysis using the R program showing let-7b in the forms of 3p and 5p strands to be the most significantly changed miRNA in the moderate to severe NE neonates with TH treatment based on outcome. F1, F3 and F5 represent favourable outcome on days 1, 3 and 5 respectively; while U1, U3 and U5 represent unfavourable outcome on days 1, 3 and 5 respectively.