Table 4.

HPV genotype distribution in vulvar HSIL and VSCC from a systematic literature search.

HPV type	Vulvar HSIL			VSCC
	(n = 1286)			(n = 3908)
	n	%	(%*)	n	%	(%*)
HPV positive	1140	88.6		1370	35.1
HPV negative	146	11.4		2538	64.9
HPV6	32	2.5	2.8	12	0.3	0.9
HPV11	10	0.8	0.9	2	0.1	0.1
HPV16	883	68.7	77.5	1026	26.3	74.9
HPV18	27	2.1	2.4	58	1.5	4.2
HPV31	32	2.5	2.8	12	0.3	0.9
HPV33	116	9.0	10.2	128	3.3	9.3
HPV35	3	0.2	0.3	10	0.3	0.7
HPV45	6	0.5	0.5	26	0.7	1.9
HPV52	7	0.5	0.6	24	0.6	1.8
HPV56	8	0.6	0.7	13	0.3	0.9
HPV58	5	0.4	0.4	12	0.3	0.9
HPV59	10	0.8	0.9	1	0.0	0.1
Other HPV types	53	4.1	4.6	65	1.7	4.7
-HR	11	0.8	1.0	13	0.3	0.9
-Probably HR	22	1.7	1.9	29	0.7	2.1
-LR	17	1.3	1.5	18	0.5	1.3
-Unclassified	3	0.2	0.3	5	0.1	0.4
Undetermined	22	1.7	1.9	27	0.7	2.0

%: the percentage of single HPV types of all included vulvar HSIL or VSCC patients, (%*): the percentage of single HPV types of HPV-positive patients. Numbers do not add up because of multiple infections. HR: high risk; LR: low risk. HR is defined as HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68. Probable HR is defined as HPV types 26, 30, 53, 66, 67, 69, 70, 73, and 82. LR is defined as HPV types 2, 6, 11, 27, 42, 43, 44, 54, 61, 62, 72, 74, 83, 84, and 89, and unclassified are types 1, 55, 114, and 120. The classification of HPV types is based on (de Villiers et al., 2004, Doorbar, 2012). In this literature search, “other HPV types” includes: (n vulvar HSIL; n VSCC) HR: HPV-39 (2;6), HPV-51 (8;4), Probable HR: HPV-5 (0;1), HPV-26 (3;3), HPV-30 (1;1), HPV-53 (2;5), HPV-66 (2;7), HPV-67 (4;1), HPV-68 (1;3), HPV-69 (0;2), HPV-70 (2;4), HPV-73 (4;3), HPV-82 (3;2), and HPV-68 or73 (1;0), LR: HPV-2 (0;1), HPV-27 (0;1), HPV-40 (1;0), HPV-42 (4;2), HPV-43 (1;0), HPV-44 (1;1), HPV-54 (2;3), HPV-61 (2;0), HPV-62 (0;1), HPV-72 (2;0), HPV-74 (0;7), HPV-83 (3;0), HPV-84 (1;0), and HPV-89 (0;2), Unclassified: HPV-1 (0;1), HPV-55 (2,0), HPV-64 (0;2), HPV-114 (1;0), and HPV-120 (0;2).