Figure 5.

Change in CRP, triglycerides, and blood pressure reflect semaglutide exposure in the PIONEER and SUSTAIN trials

Data are means and 95% CIs. Exposure is presented as quantiles of C_avg for semaglutide and 1 quantile for placebo (at C_avg of 0 nmol/L). The fitted solid line represents model-derived relations not adjusted for covariate factors, based on the PIONEER program. Triglycerides and systolic and diastolic BP: data from PIONEER 1, 2, 3, 5, 8, and 9 at week 26 and SUSTAIN 1, 2, and 3 and SUSTAIN Japan OAD at week 30. CRP: PIONEER 1, 2, and 5 data at week 26 and SUSTAIN 3 data at week 56. BP, blood pressure; CRP, C-reactive protein.