. 2021 Sep 17;13:711009. doi: 10.3389/fnagi.2021.711009

Table 1.

Demographics and clinical measures of three groups, including SCD, aMCI, and HC.

	HC(58)	SCD(44)	aMCI(49)	F-values(χ²)	P-values
Age (years)	63.328 ± 6.28	66.000 ± 7.80	63.633 ± 7.58	1.966	0.144
Gender (male/female)	25/33	8/36^**	13/36	7.865	0.020^c
Education level (years)	12.40 ± 2.52	12.33 ± 2.59	10.99 ± 2.95^*	4.359	0.014^a
MMSE scores	28.62 ± 1.24	28.34 ± 1.14	27.22 ± 1.86^*/^	13.319	<0.001^a ^b
MDRS-2	141.57 ± 2.21	139.89 ± 3.61	136.80 ± 5.10^*/^*	11.808	<0.001^a ^b
MoCA	25.11 ± 2.52	24.64 ± 1.95	22.77 ± 2.98^*/^	21.740	<0.001^a ^b
SCD-Q	3.51 ± 1.52	6.45 ± 0.89^***	5.02 ± 1.92^*/^*	46.568	<0.001^c ^a ^b
Composite Z scores of each cognitive domain
Episodic memory	0.185 ± 0.080	0.330 ± 0.093	−0.519 ± 0.090^*/^*	25.178	<0.001^a ^b
Information processing speed	0.190 ± 0.084	0.042 ± 0.098	−0.264 ± 0.095^**	6.339	0.002^a
Executive function	0.175 ± 0.065	0.147 ± 0.076	−0.330 ± 0.074^*/^*	15.166	<0.001^a ^b
Visuospatial function	0.068 ± 0.098	0.226 ± 0.114	−0.218 ± 0.111^*	3.954	0.021^b

Numbers are given as means ± standard deviation, SD unless stated otherwise. Values for age derived from ANCOVA; gender from chi-square test; all clinical measures from ANCOVA with age, gender, years of education as covariates. MMSE, mini-mental state examination; MDRS-2, Mattis Dementia Rating Scale-2; MoCA, the Montreal Cognitive Assessment test; SCD-Q, Subjective Cognitive Decline Questionnaire;

post hoc analyses showed a significant group difference between aMCI and HC;

post hoc analyses showed a significant group difference between aMCI and SCD;

post hoc analyses showed a significant group difference between SCD and HC;

p < 0.05;

^**

p < 0.01;

^***

p < 0.001;

aMCI, amnestic mild cognitive impairment; SCD, subjective cognitive decline; HC, healthy control.