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. 2021 Sep 30;12(10):893. doi: 10.1038/s41419-021-04190-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Schematic for genetic knockout screening to identify synergistic targets of alisertib in MDA-MB-231 cells. B Plot showing the distribution of CRISPR beta scores (treatment vs pretreatment) for genes targeted by the sgRNA library. Blue dots are the top 3000 negative enrichment genes. OXPHOS associated genes are highlighted. C KEGG showing significant enrichment of the OXPHOS pathway in the top 3000 negative enrichment genes. D GSEA analysis showing significant enrichment of OXPHOS and mitochondria respiration in the gene set that are induced upon 6 h alisertib treatment. E Enrichment graph of GO_Oxidative phosphorylation (NES = 2.426, p = 0) and GO_Mitochondrial inner membrane (NES = 2.345, p = 0). See also Fig. S1.