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. 2021 Sep 30;11:19496. doi: 10.1038/s41598-021-98925-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Core targets topology. The figure shows the topology of the PPI network. The color of the targets changes from blue to red according to the DC value, and red represents the core targets. The black box shows all the targets, the green box shows the targets whose DC value is greater than 1 times the median, and the blue box shows the targets whose DC value is greater than 2 times the median, which are the core targets of this study.