Table 2.
GO analysis of core targets (top 10).
| Category | Gene function | Count | P-value |
|---|---|---|---|
| BP | Response to drug | 30 | 1.05 × 10–22 |
| BP | Negative regulation of apoptotic process | 34 | 4.97 × 10–22 |
| BP | Positive regulation of transcription from RNA polymerase II promoter | 42 | 1.68 × 10–18 |
| BP | Positive regulation of transcription, DNA-templated | 32 | 2.31 × 10–18 |
| BP | Response to hypoxia | 20 | 2.55 × 10–16 |
| BP | Positive regulation of gene expression | 23 | 3.38 × 10–16 |
| BP | Cellular response to hypoxia | 16 | 2.27 × 10–15 |
| BP | Inflammatory response | 25 | 8.71 × 10–15 |
| BP | Response to estradiol | 15 | 2.50 × 10–14 |
| BP | Aging | 18 | 3.54 × 10–14 |
| MF | Enzyme binding | 32 | 5.35 × 10–24 |
| MF | Protein binding | 120 | 1.28 × 10–16 |
| MF | Identical protein binding | 32 | 7.18 × 10–14 |
| MF | Transcription factor binding | 21 | 2.29 × 10–13 |
| MF | Protein heterodimerization activity | 20 | 1.01 × 10–8 |
| MF | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | 8 | 1.58 × 10–8 |
| MF | Steroid hormone receptor activity | 9 | 1.86 × 10–8 |
| MF | Protein homodimerization activity | 24 | 3.29 × 10–8 |
| MF | Protein kinase binding | 17 | 9.26 × 10–8 |
| MF | Cytokine activity | 12 | 2.45 × 10–7 |
| CC | Extracellular space | 48 | 1.42 × 10–19 |
| CC | Membrane raft | 16 | 5.96 × 10–11 |
| CC | Extracellular region | 39 | 2.06 × 10–10 |
| CC | Cytosol | 58 | 3.83 × 10–10 |
| CC | Mitochondrion | 32 | 1.96 × 10–8 |
| CC | Caveola | 9 | 3.46 × 10–8 |
| CC | Nucleoplasm | 45 | 1.13 × 10–6 |
| CC | Extracellular matrix | 13 | 3.09 × 10–6 |
| CC | Plasma membrane | 56 | 6.49 × 10–6 |
| CC | Nucleus | 67 | 9.72 × 10–6 |