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. 2021 Sep 30;11:19412. doi: 10.1038/s41598-021-99025-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Increases in presynaptic D_2/3R, without inflammation modulation, in the midbrain of 3xTg-AD mice. (a) Schematic representation of different areas of the midbrain and hippocampus which have been drawn manually according to the acetylcholinesterase staining anatomy. (b) Example of in situ labeling with [¹²⁵I]Epidepride. Color scale refers to activity in the autoradiograms (from 0 to 500 MBq/mg). (c) Assessment of the D_2/3R density by [¹²⁵I]Epidepride specific binding ratio (SBR) quantification. (d) Example of staining at the level of the midbrain for DAPI (blue) and TH (red). (e) Quantification of the area occupied by TH staining. (f) Example of immunofluorescence for DAPI (blue), IBA1 (green) and GFAP (red) in the substantia nigra. (g) Quantification of the area occupied by IBA1 and GFAP staining. ★: p < 0.05.