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. 2021 Sep 30;11:19412. doi: 10.1038/s41598-021-99025-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Sparse Aβ deposits restricted to the subiculum and low Tau levels in the hippocampus of 3xTg-AD mice. (a–c) A weak positive labeling of amyloid plaques with MXO₄ (blue, a) and A4G8 (red, b) is observed and restricted to the subiculum. (c) Merge image of A and B. (d) A weak positive labeling for AT8 is observed only at the level of the hippocampus. (e) Example of positive AT8 cells showing positive cell bodies and neurites. (f,g) Example of immunofluorescence for DAPI (blue), IBA1 (green) and GFAP (red) in dentate gyrus (f) and dorsal hippocampus (g). (h,i) Quantification of the area occupied by IBA1 (h) and GFAP (i) staining in hippocampal subdivisions.