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. 2021 Sep 30;11:19412. doi: 10.1038/s41598-021-99025-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Behavioral alterations in 12-month-old 3xTg-AD mice. (a) Locomotor activity of WT (grey, open circles) and 3xTg-AD (blue, triangles) mice at baseline in 5 min blocks. (b) Total distance traveled, in response to saline (Sal) and quinpirole (Quin), a D₂R agonist, in WT and 3xTg-AD mice. (c) Fold change in locomotion induced by quinpirole as compared to saline. (d) From left to right, time spent in corners, intermediate areas and central square of the open field during the baseline test in WT and 3xTg-AD mice. ★: p < 0.05, ★★: p < 0.01, ★★★: p < 0.001.