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. 2021 Sep 30;13:32. doi: 10.1038/s41368-021-00135-3

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Oligodontia Family 1 from Turkey with the homozygous WNT10A exon 1 defect c.99_105dup, p.Met36CysfsTer10. a Panoramic radiographs with sites of tooth agenesis marked by stars. The proband (III:2) was the youngest at 13 years 4 months. b Pedigree of Family 1. Asterisks mark the four subjects who participated in the study. Subject genotypes are II:1 +/−, II:2 +/−, III:1 +/+, and III:2 −/−. c Oral photographs of the proband (III:2) showing marked attrition of retained primary teeth. d Summary chart of missing teeth (X, agenesis; E, extracted). The proband exhibited agenesis of 25 permanent teeth and was included in the oligodontia data analysis. e WNT10A chromatogram showing the wild-type (reference) sequence (III:1), heterozygous (II:2), and homozygous (III:2) conditions. The seven duplicated nucleotides (TGCTGCC) are indicated by blue arrows. Note the consistent dose effect of the mutation. The heterozygous parents both exhibited agenesis of two permanent teeth and the homozygous proband 25. The NCBI reference sequence designation for this WNT10A variant is NG_012179.1: g.5562_5568dup; NG_012179.1(WNT10A_v001): c.99_105dup, p.(Met36Cysfs*10)