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. 2021 Sep 17;8:723813. doi: 10.3389/fnut.2021.723813

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Copyright © 2021 Saleh, West, Ostermann, Schebb, Calder and Minihane.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simplified metabolism of ARA, EPA and DHA by, LOXs and CYPs to produce the oxylipins evaluated in this study. ARA, Arachidonic acid; EPA, Eicosapentaenoic acid; DHA, docosahexaenoic acid; LOXs, lipoxygenases; sEH, soluble epoxide hydrolase enzyme; EpETrE, epoxyeicosatrienoic acid; DiHETrE, dihydroxyeicosatrienoic acid; HETE, hydroxy-eicosatetraenoic acid; EpETE, epoxyeicosatetraenoic acid; DiHETE, dihydroxyeicosatetraenoic acids; HEPE, hydroxyeicosapentaenoic acid; EpDPE, epoxydocosapentaenoic acid; DiHDPE, dihydroxydocosapentaenoic acid; HDHA, hydroxydocosahexaenoic acid. Of note, several oxylipins can be formed by different routes as well as by chemical autoxidation.