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. 2021 Sep 17;8:723813. doi: 10.3389/fnut.2021.723813

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Copyright © 2021 Saleh, West, Ostermann, Schebb, Calder and Minihane.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bar charts showing the mean % change (with SEM) in individual EPA- (A) and DHA- (B) derived oxylipins, with their parent EPA and DHA following 12 months of supplementation with the equivalent of 4 portions of oily fish, comparing between APOE3 (n = 17) and APOE4 (n = 5/6). Independent sample t-test or Mann-Witney test was used to compare between APOE genotypes. *Statistically significant, P < 0.05, **Statistically significant, P < 0.01.