. 2021 Sep 17;8:723813. doi: 10.3389/fnut.2021.723813

Table 3.

Baseline plasma phosphatidylcholine fatty acids (% of total fatty acids; %tFA) and oxylipin concentrations (nM) in APOE3 and APOE4 individuals.

Fatty acids and oxylipins		APOE3 (n = 66)	APOE4 (n = 26)	Total (n = 92)	P_APOE	P_{parent PUFA}	*P_{APOEparent PUFA}**
EPA (%tFA)		1.11 ± 0.06	1.19 ± 0.10	1.10 ± 0.05	0.22
Hydroxy-EPA	5-HEPE	0.36 ± 0.02	0.34 ± 0.03	0.35 ± 0.02	0.84	0.02^*	0.62
	8-HEPE	0.08 ± 0.00	0.08 ± 0.01	0.08 ± 0.00	0.59	0.01^*	0.66
	9-HEPE	0.23 ± 0.01	0.23 ± 0.02	0.23 ± 0.01	0.67	0.01^*	0.72
	11-HEPE	0.11 ± 0.01	0.10 ± 0.01	0.11 ± 0.01	0.36	0.17	0.26
	12-HEPE	0.30 ± 0.03	0.30 ± 0.04	0.30 ± 0.02	0.28	0.58	0.21
	15-HEPE	0.14 ± 0.01	0.15 ± 0.02	0.14 ± 0.00	0.83	0.96	0.97
	18-HEPE	0.19 ± 0.01	0.21 ± 0.02	0.19 ± 0.01	0.51	0.06	0.78
	19-HEPE	1.02 ± 0.06	0.98 ± 0.10	1.00 ± 0.05	0.87	0.10	0.71
	20-HEPE	0.61 ± 0.04	0.68 ± 0.08	0.62 ± 0.03	0.39	0.33	0.62
	sum	3.01 ± 0.16	3.01 ± 0.25	3.01 ± 0.20	0.57	0.11	0.53
Dihydroxy-EPA	8,9-DiHETE	0.09 ± 0.01	0.08 ± 0.01	0.09 ± 0.00	0.93	0.04^*	0.77
	11,12-DiHETE	0.06 ± 0.00	0.05 ± 0.00	0.06 ± 0.00	0.66	0.02^*	0.91
	14,15-DiHETE	0.10 ± 0.00	0.09 ± 0.01	0.10 ± 0.01	0.77	0.05	0.57
	17,18-DiHETE	0.66 ± 0.03	0.62 ± 0.04	0.67 ± 0.03	0.61	0.08	0.38
	sum	0.90 ± 0.05	0.85 ± 0.05	0.87 ± 0.05	0.81	0.03^*	0.54
Epoxy-EPA	11 (12)-EpETE	<0.05	<0.05	<0.05
	14 (15)-EpETE	0.07 ± 0.01	0.07 ± 0.01	0.07 ± 0.01	0.86	0.12	0.77
	17 (18)-EpETE	<0.1	<0.1	<0.1
DHA (%tFA) Hydroxy-DHA	3.67 ± 0.12	3.73 ± 0.25	3.69 ± 0.11	0.86
	4-HDHA	0.45 ± 0.03	0.41 ± 0.03	0.50 ± 0.05	0.41	0.95	0.55
	8-HDHA	0.51 ± 0.03	0.48 ± 0.05	0.50 ± 0.02	0.19	0.22	0.22
	10-HDHA	0.12 ± 0.01	0.12 ± 0.01	0.12 ± 0.00	0.12	0.30	0.12
	11-HDHA	0.23 ± 0.01	0.20 ± 0.02	0.22 ± 0.01	0.04^*	0.96	0.08
	13-HDHA	0.11 ± 0.01	0.10 ± 0.01	0.10 ± 0.00	0.28	0.17	0.36
	14-HDHA	1.30 ± 0.12	1.08 ± 0.16	1.29 ± 0.11	0.28	0.16	0.40
	16-HDHA	0.17 ± 0.01	0.16 ± 0.01	0.17 ± 0.01	0.57	0.28	0.64
	17-HDHA	0.94 ± 0.05	0.99 ± 0.12	0.98 ± 0.05	0.30	0.51	0.20
	20-HDHA	0.44 ± 0.02	0.43 ± 0.03	0.43 ± 0.02	0.42	0.29	0.40
	21-HDHA	3.28 ± 0.16	3.12 ± 0.30	3.23 ± 0.14	0.35	0.09	0.39
	22-HDHA	2.72 ± 0.16	2.54 ± 0.22	2.75 ± 0.14	0.43	0.66	0.32
	sum	10.43 ± 0.47	10.32 ± 0.82	10.38 ± 0.6	0.16	0.18	0.16
Dihydroxy-DHA	4,5-DiHDPE	1.42 ± 0.07	1.24 ± 0.11	1.37 ± 0.06	0.42	0.99	0.65
	10,11-DiHDPE	0.23 ± 0.01	0.21 ± 0.02	0.23 ± 0.01	0.32	0.33	0.44
	13,14-DiHDPE	0.25 ± 0.01	0.23 ± 0.01	0.26 ± 0.02	0.38	0.14	0.63
	16,17-DiHDPE	0.32 ± 0.01	0.29 ± 0.02	0.33 ± 0.02	0.44	0.11	0.67
	19,20-DiHDPE	3.16 ± 0.13	2.76 ± 0.17	3.18 ± 0.15	0.31	0.05	0.62
	sum	5.48 ± 0.22	5.41 ± 0.57	5.39 ± 0.35	0.43	0.19	0.75
Epoxy-DHA	10 (11)-EpDPE	0.31 ± 0.02	0.28 ±0.03	0.3 ± 0.01	0.25	0.09	0.31
	13 (14)-EpDPE	0.25 ± 0.01	0.24 ± 0.03	0.25 ± 0.01	0.34	0.03^*	0.36
	16 (17)-EpDPE	0.27 ± 0.01	0.26 ± 0.02	0.26 ± 0.01	0.77	0.05	0.87
	19 (20)-EpDPE	0.48 ± 0.02	0.45 ± 0.04	0.47 ± 0.02	0.25	0.02^*	0.31
	sum	1.30 ± 0.06	1.30 ± 0.13	1.3 ± 0.10	0.33	0.03^*	0.39
ARA (%tFA)	9.06 ± 0.23	9.5 ± 0.40	9.19 ± 0.2	0.34
Hydroxy-ARA	5-HETE	1.35 ± 0.07	1.30 ± 0.09	1.41 ± 0.09	0.91	0.57	0.98
	8-HETE	0.31 ± 0.01	0.31 ± 0.02	0.31 ± 0.01	0.5	0.16	0.41
	11-HETE	0.27 ± 0.01	0.27 ± 0.02	0.27 ± 0.01	0.53	0.41	0.52
	12-HETE	2.05 ± 0.17	2.26 ± 0.37	2.55 ± 0.29	0.52	0.72	0.59
	15-HETE	1.00 ± 0.04	1.03 ± 0.06	1.01 ± 0.03	0.9	0.8	0.85
	20-HETE	0.93 ± 0.05	0.92 ± 0.07	0.93 ± 0.04	0.04^*	0.74	0.04^*
	sum	6.21 ± 0.12	6.55 ± 0.09	6.39 ± 0.10	0.41	0.88	0.46
Dihydroxy-ARA	5,6-DiHETrE	0.37 ± 0.04	0.27 ± 0.02	0.34 ± 0.03	0.51	0.82	0.31
	8,9-DiHETrE	0.25 ± 0.01	0.21 ± 0.01	0.24 ± 0.01	0.42	0.20	0.22
	11,12-DiHETrE	0.57 ± 0.02	0.61 ± 0.07	0.58 ± 0.02	0.82	0.19	0.95
	14,15-DiHETrE	0.65 ± 0.02	0.70 ± 0.07	0.66 ± 0.02	0.62	0.19	0.76
	sum	1.84 ± 0.05	1.68 ± 0.06	1.78 ± 0.06	0.46	0.36	0.32
Epoxy-ARA	5 (6)-EpETrE	0.9 ± 0.05	0.8 ± 0.09	0.87 ± 0.04	0.94	0.49	0.90
	8 (9)-EpETrE	0.19 ± 0.01	0.18 ± 0.02	0.19 ± 0.01	0.89	0.19	0.77
	11 (12)-EpETrE	0.20 ± 0.01	0.19 ± 0.01	0.20 ± 0.01	0.56	0.29	0.47
	14 (15)-EpETrE	0.46 ± 0.02	0.42 ± 0.03	0.45 ± 0.02	0.63	0.29	0.46
	sum	1.75 ± 0.22	1.69 ± 0.57	1.73 ± 0.37	0.57	0.50	0.94

Mean ± SEM(n) individual and sum of hydroxy-, dihydroxy- and epoxy-EPAs, -DHAs and -ARAs. P values are shown for genotype, parent PUFA and genotype*parent PUFA interaction using a univariate GLM. Age, gender, and BMI were used as covariates.

Statistically significant, P < 0.05.