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. 2021 Sep 17;12:748772. doi: 10.3389/fphar.2021.748772

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Copyright © 2021 Li, Zong, Ye, Fu, Gu, Pan, Yang, Zhang and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Histological evaluation of skin lesions (H&E staining, magnification ×200); △: microlimb swelling; ×: parakeratosis; ◇: acanthosis; ☆: lymphocyte infiltration; ○: hair follicles and sebaceous glands. (B) Immunohistochemical staining (×200) for proliferating cell nuclear antigen (PCNA) (brown) in mouse back skin. (C,D) Thickness of epidermal and PCNA⁺ cells of the skin sections of mice from each group on day 7. (E) Histogram of the spleen index of each group. (F) Body weight change in each group from day 1 to day 7. Results were shown as the mean ± SD. **p < 0.01 or ***p < 0.001 vs. IMQ group.