Figure 8.

Training for 9 weeks increases mice survival from lethal listeriosis. Control mice and mice trained 1 week and 9 weeks before infection were challenged i.v. with 1.7 x 10⁴ CFU L. monocytogenes. (A) Blood was collected 2 days after infection to quantify cytokines (IL-1β, IL-6, IL-10, IL-12p40, IL-17A, IL-18, IFNγ, TNF, CCL2, CXCL1, and CXCL5). Heatmap and hierarchical clustering of cytokine levels was performed using Z-score normalization. (B, C) Weight loss (expressed in percentage of initial weight) and survival of mice. Data are means ± SD (B). *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 vs. control.