TABLE 1.

ASIC subtypes and their pH sensitivity.

Gene	Subtype	Alternative names	pH sensitivity (pH50)1
ASIC1	ASIC1a	ASIC, ASICα, BNaC2(α)	5.8–6.8
	ASIC1b	ASICβ, BNaC2(β)	6.1–6.2
ASIC2	ASIC2a	BNaC1(α), MDEG, BNC(1a)	4.5–4.9
	ASIC2b	BNaC1(β), MDEG2	Does not form pH-sensitive homomers; associates with other ASICs to form pH-sensitive channels
ASIC3	ASIC3	DRASIC, TNaC1, SLNAC1	6.4–6.6
ASIC4	ASIC4	BNAC4, ACCN4, SPASIC	Does not form pH-sensitive homomeric channels

¹The pH sensitivities of the homomeric ASIC channels are from Wemmie et al. (2013).