Table 2.

IL-6 receptor blockade has no effect on total fat and carbohydrate oxidation

	Lean			Obese
	Saline	IL-6R ab (day 1)	IL-6R ab (day 21)	Saline	IL-6R ab (day 1)	IL-6R ab (day 21)
RER
Rest	0.73 ± 0.01	0.75 ± 0.01	0.73 ± 0.01	0.74 ± 0.01	0.74 ± 0.01	0.74 ± 0.01
Exercise	0.85 ± 0.01	0.86 ± 0.01	0.86 ± 0.01	0.85 ± 0.01	0.85 ± 0.01	0.86 ± 0.01
Recovery	0.71 ± 0.01	0.72 ± 0.01	0.72 ± 0.01	0.72 ± 0.01	0.72 ± 0.01	0.73 ± 0.01
Oxygen uptake (mL/min)
Rest	287 ± 5	280 ± 8	298 ± 10	349 ± 11	338 ± 10	348 ± 11
Exercise	2,183 ± 72	2,159 ± 67	2,145 ± 68a	2,066 ± 140	2,025 ± 144	2,036 ± 134
Recovery	308 ± 6	299 ± 7	313 ± 10	372 ± 9	357 ± 12b	365 ± 13
Total fat oxidation (mg/min/kg)
Rest	1.64 ± 0.09	1.52 ± 0.07	1.71 ± 0.07	1.36 ± 0.07	1.29 ± 0.08	1.31 ± 0.06
Exercise	7.05 ± 0.43	6.56 ± 0.52	6.36 ± 0.47	4.31 ± 0.38	4.22 ± 0.29	4.07 ± 0.43
Recovery	1.98 ± 0.08	1.89 ± 0.08	1.89 ± 0.07	1.56 ± 0.09	1.47 ± 0.07	1.48 ± 0.08
Total carbohydrate oxidation (mg/min/kg)
Rest	0.54 ± 0.17	0.67 ± 0 0.17	0.44 ± 0.17	0.49 ± 0.14	0.52 ± 0.14	0.52 ± 0.14
Exercise	17.81 ± 0.79	18.92 ± 0.79	19.00 ± 0.82	12.42 ± 1.60	12.36 ± 1.60	12.81 ± 1.60
Recovery	0.19 ± 0.09	0.27 ± 0.09	0.31 ± 0.09	0.30 ± 0.12	0.32 ± 0.12	0.38 ± 0.12

Data are represented as mean ± SEM.

^ap < 0.01 versus saline day, using a linear mixed-effects model and Dunnett’s method for many-to-one comparisons. IL-6R ab, IL-6 receptor antibody; RER, respiratory exchange ratio.

^bp < 0.05 versus saline day using a linear mixed-effects model and Dunnett’s method for many-to-one comparisons.