Figure 3.

F. prausnitzii isolates improved Aβ-induced cognitive impairment

12 live isolates of F. prausnitzii were administered orally to mice that were injected i.c.v. with Aβ25-35. Cognitive performance was evaluated by Y-maze test and PA test.

(A) Bar plot showing total entry time in the Y-maze test.

(B) Bar plot showing the alternation ratio in the Y-maze test.

(C) Bar plot showing the latency time of the acquisition trial in the PA test.

(D) Bar plot showing the latency time of the test trial in the PA test.

All values are expressed as the mean + SE (n = 9, biological replicates). ∗∗p < 0.01 by two-sided unpaired Student’s t test (sham operation versus vehicle); #p < 0.05, ##p < 0.01 by two-sided unpaired Student’s t test (versus culture medium); ††p < 0.01 by two-sided unpaired Student’s t test (versus vehicle).