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. 2021 Sep 14;2(9):100398. doi: 10.1016/j.xcrm.2021.100398

Figure 4.

Figure 4

The selected Fp14 and Fp360 improved Aβ-induced cognitive impairment in different bacterial forms (pasteurized or live)

Live Fp14 or Fp360, pasteurized Fp14 or Fp360, and their corresponding culture supernatant were administered orally to mice that were injected i.c.v. with Aβ25-35. Cognitive performance was evaluated by Y-maze test and PA test.

(A) Bar plot showing total entry time in the Y-maze test.

(B) Bar plot showing the alternation ratio in the Y-maze test.

(C) Bar plot showing the latency time of the acquisition trial in the PA test.

(D) Bar plot showing the latency time of the test trial in the PA test.

All values are expressed as the mean + SE (n = 12, biological replicates). ∗∗p < 0.01 by two-sided unpaired Student’s t test (sham operation versus vehicle); #p < 0.05, ##p < 0.01 by two-sided unpaired Student’s t test (versus culture medium); †p < 0.05, ††p < 0.01 by two-sided unpaired Student’s t test (versus vehicle). See also Figure S4.