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. 2021 Sep 17;12:733048. doi: 10.3389/fgene.2021.733048

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Copyright © 2021 Sumya, Pokrovskaya and Lupashin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased accumulation of core proteins of HSPGs (Heparin sulfate proteoglycans) on the cell surface of rescued mutant (G516R and R729W) RPE1 cell line. (A) RPE1 rescued COG4-WT-3myc, COG4-G516R-3myc, and COG4-R729W-3myc cells were digested by the Heparinase III enzyme. Western blot analysis with 3G10 antibody to the core proteins of proteoglycan (HSPGs). (B) Quantitative analysis of the core proteins of HSPGs accumulation. Statistical significance was calculated by GraphPad Prism 8 using One-way ANOVA. **p ≤ 0.01, ***p ≤ 0.001. Error bar represents mean ± SD.