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. 2021 Sep 17;9:724310. doi: 10.3389/fcell.2021.724310

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Copyright © 2021 Zhang, Huang, Fu, Liu, Wang, Wang, Qu, Li, Fan, Hu and Miao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kyoto Encyclopedia of Genes and Genomes and GO analysis of differentially expressed genes in 3D cultured dermal papilla cells. (A) Blue and red circles indicate metabolism and human diseases, respectively. The green circle indicates environmental information processing, whereas the brown circle represents organismal systems. The purple and yellow circles indicate cellular processes and genetic information processing, respectively. The size of the bubble represents the rich factor (gene number/total gene number), the y-axis represents –log10(Q-value), and the x-axis represents the normalized number of upregulated genes minus downregulated genes. (B) GO analysis of DEGs in 3D. Yellow: biological process, green: cellular component. From exterior to interior: first layer indicates the top 20 GO terms with the coordinate ruler indicating the number of genes presented external to the circle. Second layer (red): total number of genes in the GO term and –log10(Q-value), wherein a higher number of genes corresponds to a longer section, larger –log10(Q-value), and darker shade of red. Third layer: upregulation/downregulation gene ratio bar chart, wherein dark purple represents the upregulated gene proportion, light purple represents the downregulated gene proportion, and the specific value is shown below. Fourth layer: enrichment factor for each term (number of genes/total number of genes), with each small cell of the background auxiliary line representing 0.1. The chart on the right shows the gene symbols corresponding to the top 20 GO IDs. DEGs, differentially expressed genes.