Table 1.

Known features of the Tim family.

Molecule	Expressing cells	Ligand(s)	Function	Disease	Ref
Tim-1	Activated Th2 cells, Bregs	Tim-4 PS	Costimulation of T cell activation, modulation of Treg function, maintenance and induction of Bregs	Autoimmune diseases, infection, asthma, allergy	(12, 20)
Tim-3	Th1 cells, innate immune cells	Gal-9 HMGB1 Ceacam1 PS	Suppression of the Th1 response, increased activation of signaling pathways leading to T cell activation	Autoimmune diseases, infection, cancer	(13, 21)
Tim-4	APCs	Tim-1 PS	Regulation of T cell proliferation, clearance of apoptotic cells	Autoimmune diseases, chronic metabolic disease, infection, allergy	(15, 22)