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. 2021 Sep 17;12:714138. doi: 10.3389/fimmu.2021.714138

Figure 1.

Figure 1

Formyl peptide receptor 1 (FPR1), FPR2, and annexin A1 (AnxA1) are differentially expressed in the colon of Crohn’s disease (CD) responders to infliximab (IFX) and correlate with histological homeostasis. (A) Heatmap based on the Z-scores of FPR1, FPR2, and AnxA1 expression values in the colon. (B–E) Confocal imaging: negative control of reaction (B), FPR1 (C), FPR2 (D), and AnxA1 (E) tissue staining. Embedding, paraffin; sections, 3 μm. Bar, 20 μm. (F) Histological grading, calculated based on Supplementary Table 1. (G–I) Densitometric analysis of fluorescence: FPR1 (G), FPR2 (H), and AnxA1 (I). (J–L) Correlation analysis between histological grading of biopsies and fluorescence intensity of staining: FPR1 (J), FPR2 (K), and AnxA1 (L). *p < 0.05, **p < 0.01. n = 4 (CD untreated); n = 3 (Remission); n = 2 (Failure). Results are expressed as the mean ± SD.