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. 2021 Sep 17;12:714138. doi: 10.3389/fimmu.2021.714138

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Copyright © 2021 de Paula-Silva, da Rocha, Broering, Queiroz, Sandri, Loiola, Oliani, Vieira, Perretti and Farsky

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Crypt regeneration mediated by infliximab (IFX) requires formyl peptide receptor (FPR) signaling. (A) Control: cylindrical-shaped cells forming a U-shaped crypt revealed by β-actin staining (a1, red). Presence of villin (a2, green) in the inner surface from the excretory part of the crypt lumen. Representation of a normal structure. (B) DSS+IFX: preserved crypt morphology resembling the control condition (b1 and b2). (C) DSS+IFX+Boc-2: defects in crypt closure (c1); presence of villin (c2 and c3, white arrowheads); and DNA residue (c2 and c3, black arrowheads) in the crypt lumen. n = 4–6 mice/group. Embedding, paraffin; sections, 3 μm. Bars, 20 μm.