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. 2021 Sep 17;12:702072. doi: 10.3389/fgene.2021.702072

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Copyright © 2021 Fang, Qu, Wang, Tang, Yan, Ma and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Two m⁶A methylation modification patterns with distinct immune cell infiltration, biological functions, and genetic mutation. (A) Heatmap of expression patterns of m⁶A regulators in m⁶A clusters (cluster A and B), OS status, stage, age, and sex. (B) Associations between immune cells and prognoses of pancreatic cancer. HR: hazard ratio and CI: confidence interval. (C) Box plot of the infiltration levels of immune cells in two m⁶A clusters. Ns: not significant; *p < 0.05; **p < 0.01. (D) GSVA enrichment analysis for the activation status of biological pathways in two m⁶A clusters. (E) Box plots of the enrichment scores of key biological processes in two m⁶A clusters. (F) The somatic mutation landscape of samples in m⁶A cluster A. (G) The somatic mutation landscape of samples in m⁶A cluster B.