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. 2021 Sep 17;9:736994. doi: 10.3389/fcell.2021.736994

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Copyright © 2021 Yuan, Chen, Yao, Zeng, Xie, Shafiq, Noman and Jiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Hierarchical Ward-linkage clustering based on the Pearson correlation coefficients of the relative abundance of operational taxonomic units in IVF and tissue microbiota of 20 individuals with colorectal cancer (CRC). Bacterial clusters were defined based on the clusters in the vertical tree and named after their most notable characteristic. Column color coding is according to the legend below. The right shows the most abundant bacterial genera, and the most strongly connected genera in each bacterial cluster (i.e., genera with the highest numbers of significant positive correlations with other members of each respective group) are listed. (B) Boxplots of the relative abundances of the six co-abundance groups (CAGs) of bacterial clusters, **p < 0.01. (C) Hierarchical Ward-linkage clustering based on the Pearson correlation coefficients of the relative abundance of CAGs in CRC samples (20 individuals).