TABLE 1.
Characteristics of 12 A. ustus isolates and in vitro susceptibility to amphotericin B, itraconazole, voriconazole, and terbinafine
| Isolate no.a | Date of isolation (day/mo/yr) | Originb | Aspergillus infection | MIC (μg/ml)/MFC (μg/ml)c
|
|||
|---|---|---|---|---|---|---|---|
| AmB | ITZ | VCZ | TBF | ||||
| AZN677 | 9/12/1992 | BAL, case patient | Proven | 2/2 | 2/16 | 8/16 | 0.25/0.25 |
| AZN678 | 15/12/1992 | Sputum, case patient | Proven | 2/2 | 2/32 | 4/32 | 0.25/0.25 |
| AZN682 | 25/12/1992 | Autopsy, lung, case | Proven | 2/2 | 4/16 | 8/8 | 0.5/0.5 |
| AZN741 | 26/1/1993 | Hematology ward, room | 2/2 | 2/32 | 8/16 | 0.5/0.5 | |
| AZN924 | 7/5/1993 | Hematology ward, room | 2/2 | 2/32 | 4/8 | 0.5/0.5 | |
| AZN943 | 14/7/1993 | Laboratory contaminant | 2/2 | 2/32 | 4/16 | 0.5/0.5 | |
| AZN2725 | 23/1/1995 | Sputum, patient in ENT department | No infection | 2/2 | 8/32 | 4/16 | 0.5/0.5 |
| AZN3297 | 15/6/1995 | Feces, patient in neurology department | No infection | 2/2 | 2/32 | 4/4 | 0.5/0.5 |
| AZN6989 | 22/9/1997 | Ascites, HIV+ patient | No infection | 2/2 | 2/32 | 2/8 | 0.5/0.5 |
| AZN7134 | 15/12/1997 | Hematology ward, room | 2/2 | 2/32 | 4/32 | 0.5/0.5 | |
| CBS239.90 | 1990 | Biopsy of brain abscess | Proven | 2/2 | 1/1 | 0.25/0.25 | 0.06/0.06 |
| A252 | 1/2/1994 | Needle biopsy of lung | Proven | 2/2 | 2/32 | 4/8 | 0.5/0.5 |
a
AZN numbers refer to isolates cultured at the University Hospital Nijmegen, Nijmegen, The Netherlands; isolate CBS239.90 was cultured at the University Hospital Utrecht, Utrecht, The Netherlands; isolate A252 was cultured at Hôpital Henri Mondor, Créteil, France.
b
BAL, bronchoalveolar lavage specimen; ENT, ear-nose-throat; HIV+, human immunodeficiency virus positive.
c
AmB, amphotericin B; ITZ, itraconazole; VCZ, voriconazole; TBF, terbinafine.