Fig. 2.
Overall structure of the GARPECD:TGF-β1:MHG-8 Fab complex (Figure from Liénart et al., Science, 2018). a Cartoon representations of the tridimensionnal structure of GARPECD:TGF-β1:MHG-8Fab complexes , as determined by X-ray crystallography. MHG-8 : anti-human GARP:TGF-β1 mAb ; ECD : extracellular domain. Latent TGF-β1 is composed of two LAP monomers (LAPA and LAPB) and two mature TGF-β1 monomers (mTGF-β1A and mTGF-β1B). Red dashed line: region located between the the transmembrane domain and the large extracellular, leucine-rich-repeat containing domain of GARP (juxta-membrane region not present or solved in the crystals). b Cartoon representation of a different view of the GARP:TGF-β1 complex without the MHG-8 Fab, not illustrated for clarity. c Schematic representation of protein components participating in the GARPECD:TGF-β1 complex. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)