Table 3.
Selected key peptides present in control (normal) brain but not GBM.
| Protein | Sequence | −10logP | Mass | Length | ppm | m/z | RT |
|---|---|---|---|---|---|---|---|
| ProSAAS Peptides | |||||||
| GAV | SVPRGEAAGAVQELARALAHLLEAERQE | 58.37 | 2970.564 | 28 | 1.2 | 743.649 | 72.63 |
| PEN (mouse)/PEG (Human) | AADHDVGSELPPEGVLGALL | 50.86 | 1958.995 | 20 | 0.3 | 980.505 | 70.65 |
| Little SAAS | GLSAASPPLAETGAPRRF | 43.71 | 1796.953 | 18 | −1.4 | 599.9908 | 44.21 |
| SAAS | ARPVKEPRGLSAASPPLAETGAPRRF | 39.13 | 2730.504 | 26 | 1.4 | 547.1089 | 39.49 |
| Cholecystokinn Peptides | |||||||
| QPVPPADPAGSGLQRAEEAPRRQL | 48.67 | 2522.299 | 24 | −0.7 | 841.7729 | 45.78 | |
| QPVPPADPAGSGLQRAEEAPRRQ | 46.89 | 2409.215 | 23 | −1.6 | 804.0776 | 41.2 | |
| ADPAGSGLQRAEEAPRRQL | 45.43 | 2021.04 | 19 | −2 | 1011.525 | 35.43 | |
| DPAGSGLQRAEEAPRRQL | 32.08 | 1950.003 | 18 | −2.1 | 651.007 | 35.68 | |
| Secretogrannin-1 Peptides | |||||||
| QYDRVAQLDQLLHY | 47.53 | 1743.858 | 14 | 1.4 | 872.9375 | 65.21 | |
| NLARVPKLDL | 41.77 | 1137.687 | 10 | 0.1 | 569.8508 | 46.71 | |
| KNFFPEYNY | 20.44 | 1220.55 | 9 | 4.8 | 611.2853 | 51.56 | |
| Secretogrannin-2 Peptides | |||||||
| TNEIVEEQYTPQSLATLESVFQELGKLTGPNNQ | 53.6 | 3676.811 | 33 | −0.1 | 1226.611 | 83.6 | |
| FPVGPPKNDDTPNR | 40.36 | 1552.763 | 14 | 0.3 | 777.3892 | 34.63 | |
| FPVGPPKNDDTPNR | 19.73 | 1609.785 | 14 | 0.5 | 537.6025 | 34.56 | |
| GQGSSEDDLQEEEQIEQAIKEHLNQGSSQETDKLAPVS | 16.71 | 4152.92 | 38 | 2.2 | 1385.317 | 58.72 | |
| Secretogrannin-3 Peptides | |||||||
| ELSAERPLNEQIAEAEED | 49.36 | 2041.944 | 18 | 1.3 | 1021.981 | 47.64 | |
| Cocaine- and amphetamine-regulated transcript | |||||||
| ALDIYSAVDDASHEKELIEALQEVLKKL | 58.27 | 3139.665 | 28 | 1.2 | 628.941 | 79.87 | |
| Neurogrannin Peptides | |||||||
| ARKKIKSGERGRKGPGPGGPGGAGVARGGAGGGPSGD | 32.75 | 3312.762 | 37 | 0 | 474.259 | 26.77 | |
| PGANAAAAKIQASFRGHMARKKIKSGERGRKGPGPGGPGGAGVARGGAGGGPSGD | 21.4 | 5148.684 | 55 | −0.1 | 736.5334 | 32.05 | |
| DPGANAAAAKIQASFRGHMARKKIKSGERGRKGPGPGGPGGAGVARGGAGGGPSGD | 16.42 | 5263.71 | 56 | 1.3 | 658.9719 | 32.91 | |
| PGANAAAAKIQASFRGHMARKKIKSGERGRKGPGPGGPGGAGVARGGAGGGPSGD | 14.08 | 5148.684 | 55 | 1.5 | 644.5937 | 32.05 | |
| Neuropeptide Y | |||||||
| SPETLISDLLMRESTENVPRTRLEDPAMW | 85.85 | 3472.7 | 30 | 1 | 1158.574 | 60.45 | |
| YPSKPDNPGEDAPAEDMARYYSALRHYINL | 80.68 | 3452.61 | 30 | 0.1 | 864.16 | 54.8 | |
-10logP = measure of confidence in sequence matching; ppm = parts per million; m/z = mass to charge ratio; RT = retention time; length refers to peptide length detected. The peptides identified were CCK-18, CCK-19, CCK-23 and CCK-24.