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. 2021 Sep 17;12:744494. doi: 10.3389/fphar.2021.744494

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Copyright © 2021 Guo, Li, Sun, Wang, Yang, Jiao and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptome analysis of ATCC19606-R after exposure to colistin (2 μg/mL) alone or the combination of colistin (2 μg/mL) plus capsaicin (32 μg/mL). (A): Differential gene volcano map. (B): KEGG enrichment analysis of up-regulation genes. (C): KEGG enrichment analysis of down-regulation genes; the color of the dot represents the size of the Q value, and the size of the dot represents the number of differential genes. (D): Differentially expressed genes of ribosomes, multidrug efflux pump and outer membrane lipoprotein. Col: colistin alone; Col + Cap: the combination of colistin and capsaicin.