TABLE 5.

Validation^† of drug-likeness of the benzopyrazines (1–11).

Compound	miLogPa	HBAb	HBDc	TPSAd	RBe	MWf	Violation
1	2.96	2	0	24.73	1	212.30	0
2	4.62	2	0	24.73	2	288.39	0
3	3.41	2	0	25.78	1	206.25	0
4	3.44	3	0	35.02	2	236.27	0
5	4.06	2	0	25.78	1	240.69	0
6	3.34	5	0	71.61	2	251.25	0
7	5.91	5	0	71.61	3	355.40	1
8	5.34	5	0	71.61	3	363.32	1
9	3.56	5	0	71.61	2	265.27	0
10	5.08	2	0	25.78	2	282.35	1
11	5.01	5	0	71.61	3	327.34	1

^† Molinspiration property engine v2018.10.

^amiLogP: Moriguchi octanol-water partition coefficient, is based on quantitative structure-LogP relationships, by using topological indexes.

^bHydrogen bond acceptor.

^cHydrogen bond donor.

^dTotal polar surface area.

^eNumber of rotatable bonds.