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. 2021 Sep 17;11:737827. doi: 10.3389/fonc.2021.737827

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Copyright © 2021 Wu, Wang, Liao, Rao, Gong, Ou, Chen and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A 46-year-old woman with a newly diagnosed lung cancer underwent [¹⁸F]FDG and [⁶⁸Ga]Ga-DOTA-FAPI-04 PET/CT (A, B). The MIP images (A, B) of the [¹⁸F]FDG and [⁶⁸Ga]Ga-DOTA-FAPI-04 PET/CT showed multiple bone lesions. On the selected axial images, [¹⁸F]FDG PET/CT (A) only showed mild to moderate [¹⁸F]FDG activities on thoracic vertebrae (arrows) and right acetabulum (dashed arrows), whereas [⁶⁸Ga]Ga-DOTA-FAPI-04 PET/CT (B) showed intense [⁶⁸Ga]Ga-DOTA-FAPI-04 uptakes in thoracic vertebrae (arrows) and right acetabulum (dashed arrows).