Table 2.

Multivariate Cox regression for postoperative mortality.

Categories	Variables	Univariate analysis	Multivariate analysis
		p value	HR (95% CI)	p value
Adjuvant therapy for primary cancer	Chemotherapy	0.45
	Radiotherapy	0.043	3.02 (1.14-8.01)	0.027
	Endocrine therapy	0.9
Subtype	(Luminal A=1, LuminalB=2, Her2-enhanced=3, Triple-negative=4)	<0.001	2.1 (1.4-3.2)	<0.001
location	Limb	0.88
	Pelvis	0.44
	Spine	0.49
Bone condition	multiple bone metastases (1metastasis=1, 2-3metastases=2, ≥4metastases=3)	<0.001	1.55 (0.92-2.60)	0.098
	Pathological fracture	0.035	–	–
	Surgery methods (Palliative surgery=1, Radical surgery=2)	0.036	–	–
Viscera metastasis	LN metastasis	0.061	2.80 (1.08-7.22)	0.034
	Brain metastasis	0.041	–	–
	Liver metastasis	0.002	–	–
	Lung metastasis	0.012	–	–
	Other organ metastasis	0.036	–	–
Adjuvant therapy for metastasis	Chemotherapy for metastasis	0.12
	Radiotherapy for metastasis	0.71
	Endocrine therapy for metastasis	0.98
Age	Age at primary cancer n ≤ 49 = 0, n>49 = 1	0.18
	Age at metastasis n ≤ 53 = 0, n>53 = 1	0.31
	Disease free interval(DFI) n ≤ 5 = 0, n>5 = 1	0.53
Tumor marker	CEA	0.57
	CA125	<0.001	1.005 (1.001-1.008)	0.009
	CA153	0.98
Serum biomarkers	WBC	0.28
	RBC	0.15
	Hemoglobin(HB)	0.004	–	–
	Bilirubin, total	0.28
	Total protein	0.55
	ALT	0.75
	ALP	0.002	–	–
	Total bile acid	0.7
	AST	0.37
	LDH	<0.001	1.007 (1.002-1.012)	0.003
	Total cholesterol	0.33
	Ca	0.52
	P	0.33
	Urea nitrogen	0.4
	Creatinine	0.84
	Uric acid	0.76
	Glucose	0.85

HR, hazard ratio; CI, confidence interval; LN, lymph node; CEA, carcinoembryonic antigen; CA125, Carbohydrate antigen125; CA153, Carbohydrate antigen153; WBC, white blood cell count; RBC, red blood cell count; HB, hemoglobin; ALT, alanine aminotransferase; ALP, alkaline phosphatase; AST, Aspartate aminotransferase; LDH, lactate dehydrogenase; Ca, calcium; Mg, magnesium.