Table 2.
Diagnostic performance of miRNAs in patients with PCNSL.
| Analysis | Overall | CSF-based | Blood-based | MiR-21 | Non-miR-21 |
|---|---|---|---|---|---|
| No. of studies | 11 | 6 | 4 | 4 | 7 |
| SEN (95% CI) | 0.91 (0.84-0.95) | 0.92 (0.81-0.97) | 0.86 (0.79-0.91) | 0.89 (0.82-0.93) | 0.91(0.81-0.96) |
| I2 (P value) | 68.33 (<0.001) | 81.10 (<0.001) | 0.00 (0.41) | 21.35 (0.28) | 79.17 (<0.001) |
| SPE (95% CI) | 0.88 (0.84-0.91) | 0.85 (0.78-0.90) | 0.89 (0.85-0.92) | 0.89 (0.85-0.93) | 0.86 (0.79-0.90) |
| I2 (P value) | 0.00 (0.50) | 0.00 (0.50) | 0.00 (0.47) | 0.00 (0.70) | 0.00 (0.43) |
| PLR (95% CI) | 7.48 (5.71-9.78) | 6.10 (4.10-9.20) | 7.79 (5.55-10.93) | 8.39 (5.88-11.97) | 6.38 (4.25-9.58) |
| I2 (P value) | 0.00 (0.39) | 0.00 (0.48) | 0.00 (0.36) | 0.00 (0.76) | 0.00 (0.30) |
| NLR (95% CI) | 0.11 (0.06-0.19) | 0.09 (0.04-0.24) | 0.15 (0.10-0.24) | 0.13 (0.08-0.20) | 0.10 (0.04-0.24) |
| I2 (P value) | 71.06 (<0.001) | 82.79 (<0.001) | 0.00 (0.42) | 10.51 (0.34) | 81.25 (<0.001) |
| DOR (95% CI) | 70 (35-142) | 65 (21-207) | 50 (27-93) | 66 (34-127) | 62 (21-189) |
| I2 (P value) | 99.88 (<0.001) | 99.80 (<0.001) | 82.26 (<0.001) | 60.29 (0.06) | 99.85 (<0.001) |
| AUC | 0.90 (0.87-0.92) | 0.88 (0.85-0.91) | 0.94 (0.91-0.96) | 0.95 (0.93-0.97) | 0.91 (0.88-0.93) |
No., number; SEN, sensitivity; SPE, specificity; PLR, positive likelihood ratio; NLR, negative likelihood ratio; DOR, diagnostic odds ratio; AUC, area under the curve; 95% CI, 95% confidence interval; CSF, cerebrospinal fluid.