Table 3.
HIV-Related Characteristics of MACS Men and WIHS Women Living With HIV at Their 2018–2019 Study Visit
| All PLWH (n = 2,492) | Prevalence Among PLWH, % | ||||
|---|---|---|---|---|---|
| HIV Characteristic at Most Recent Study Visit | No. | % |
Men (n = 1,004) |
Women (n = 1,488) |
P Value |
| HIV serostatus | |||||
| HIV-seroprevalent | 2,236 | 90 | 76 | 99 | <0.001 |
| HIV-seroincident (seroconversion since enrollment in study) | 256 | 10 | 24 | 1 | |
| CD4 cell count nadir, cells/mm3 | <0.001 | ||||
| ≥500 | 263 | 11 | 12 | 10 | |
| 350–499 | 427 | 17 | 21 | 15 | |
| 200–349 | 813 | 33 | 35 | 31 | |
| <200 | 989 | 40 | 33 | 44 | |
| Current CD4 cell count, cells/mm3 a | |||||
| <350 | 315 | 13 | 12 | 14 | 0.13 |
| <200 | 107 | 5 | 3 | 5 | 0.01 |
| Current HIV viral RNA loadb | 0.06 | ||||
| Not detected (<20 copies/mL) | 1,765 | 74 | 77 | 73 | |
| Detected (≥20 copies/mL) | 606 | 26 | 23 | 27 | |
| Ever use of ART | 0.98 | ||||
| Never used | 47 | 2 | 2 | 2 | |
| Ever used | 2,445 | 98 | 98 | 98 | |
| Current use of ART | 2,328 | 93 | 96 | 92 | <0.001 |
| ART adherence among those currently receiving treatment | |||||
| 100% adherent | 1,185 | 51 | 49 | 52 | 0.14 |
| ≥95% adherent | 2,088 | 90 | 92 | 88 | 0.003 |
| History of clinical AIDS | 607 | 24 | 11 | 33 | <0.001 |
| Time from estimated HIV seroconversion to most recent visitc, yearsd | 23 (12–30) | 24 (12–30) | 17 (11–20) | 0.02 | |
| CD4 cell count nadir, cells/mm3 d | 241 (125–366) | 273 (159–393) | 223 (106–346) | <0.001 | |
| Current CD4 cell count, cells/mm3 d | 669 (470–903) | 644 (476–850) | 689 (463–930) | 0.01 | |
| HIV viral RNA load, log10 copies/mL (among those detected)d | 2.1 (1.6–3.5) | 1.8 (1.6–2.5) | 2.2 (1.6–3.9) | <0.001 | |
| Years since ART initiation (among current users)d | 16.9 (8.6–23.2) | 20.3 (9.9–27.7) | 13.3 (8.3–22.3) | <0.001 | |
Abbreviations: AIDS, acquired immunodeficiency syndrome; ART, antiretroviral therapy; CD4, cluster of differentiation 4; HIV, human immunodeficiency virus; MACS, Multicenter AIDS Cohort Study; PLWH, people living with HIV; WIHS, Women’s Interagency HIV Study.
a Among participants with a known current CD4 cell count (n = 2,372).
b Among participants with a known current HIV viral RNA load (n = 2,371). HIV viral RNA load in the past 2 years was unknown (not measured) among 10% of men (these were primarily men who completed a telephone visit only) and 1% of women.
c Calculated among the 256 participants with known HIV seroconversion (“seroincident”) during study follow-up.
d Values are presented as median (interquartile range).