Table 6.
Numbers of Participant Visits With Samples in the MACS/WIHS Combined Cohort Study Biorepository as of May 1, 2020, and the Time Period During Which Each Type of Sample Was Collected in the MACS and WIHS
| Specimen Type | No. of Participant Visits | Date Range of Data Collected | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All Participants (Active, Censored, and Deceased) | Current Participants (n = 4,016) | |||||||||||
| Total | Men | Women | Total | Men | Women | Men (MACS) | Women (WIHS) | |||||
| PLWH | HIV-SN | PLWH | HIV-SN | PLWH | HIV-SN | PLWH | HIV-SN | |||||
| Serum | 224,856 | 68,500 | 63,908 | 68,968 | 23,480 | 120,521 | 33,240 | 33,285 | 39,105 | 14,891 | 1984–2019 | 1994–2019 |
| Plasmaa | 225,277 | 68,665 | 63,769 | 69,379 | 23,464 | 107,922 | 39,122 | 14,839 | 39,122 | 14,839 | 1984–2019 | 1994–2019 |
| Plasma EDTA | 45,764 | 21,215 | 20,562 | 2,824 | 1,163 | 58,010 | 38,043 | 16,021 | 2,798 | 1,148 | 2006–2019 | 2014–2019 |
| Peripheral blood mononuclear cells | 217,167 | 63,825 | 62,509 | 67,741 | 23,092 | 105,938 | 38,352 | 14,617 | 38,352 | 14,617 | 1994–2019 | 1994–2019 |
| Cell pellets | 88,355 | 1,499 | 1,309 | 63,440 | 22,107 | 53,974 | 946 | 856 | 37,691 | 14,481 | 1994–2019 | 1994–2019 |
| Urine (clean void)b | 43,453 | 12,558 | 12,481 | 14,109 | 4,305 | 60,924 | 39,105 | 14,891 | 4,955 | 1,973 | 1984–2014 | 1994–2019 |
| Urine (supernatant)b | 35,039 | N/A | N/A | 25,919 | 9,120 | 21,546 | N/A | N/A | 15,253 | 6,293 | NC | 1994–2019 |
| Cervicovaginal lavage | 91,853 | N/A | N/A | 67,390 | 24,463 | 54,064 | N/A | N/A | 38,043 | 16,021 | NC | 1994–2019 |
| Oral samplec | 7,512 | 669 | 1,000 | 4,773 | 1,070 | 2,165 | 121 | 235 | 1,437 | 372 | 1984–1993 | 1995–2004 |
| B-cell lines | 3,354 | 2,655 | 699 | N/A | N/A | 704 | 509 | 195 | N/A | N/A | N/A | NC |
| Stool | 6,851 | 3,252 | 3,599 | N/A | N/A | 3,946 | 2,798 | 1,148 | N/A | N/A | 1984–1985 | NC |
| Semen | 21,557 | 10,290 | 11,267 | N/A | N/A | 1,809 | 1,437 | 372 | N/A | N/A | 1984–1993 | NC |
Abbreviations: AIDS, acquired immunodeficiency syndrome; EDTA, ethylenediaminetetraacetic acid; HIV, human immunodeficiency virus; MACS, Multicenter AIDS Cohort Study; N/A, not applicable; NC, not collected; PLWH, people living with HIV; SN, seronegative; WIHS, Women’s Interagency HIV Study.
a Plasma samples were stored in cell preparation tubes containing the anticoagulants heparin and sodium citrate for the MACS and WIHS, respectively.
b Oral samples were throat washes in the MACS and saliva samples in the WIHS.
c Urine was collected at every visit during selected periods (men: 1984–1991 and 2009–2014; women: 1994–1998 and annually from 2009 to 2019).