Table 6.
Relationships between clinicopathological variables of NSCLC patients and CD40 rs1883832 genotypes.
| Clinicopathological characteristics | Patients | Genotypes | p-value | Genotypes | p-value | ||
| n (%) | CC | CT+TT | TT | CC+CT | |||
| Total | 229 (100) | ||||||
| Genotyped | 228 (99.6) | 113 (49.3) | 115 (50.2) | 54 (23.6) | 174 (76.0) | ||
| NA | 1 (0.4) | ||||||
| Age (years) Mean (range) | 65 (40–84) | ||||||
| Genotyped | 228 (100) | 39 (17.1) | 74 (32.5) | 0.584 | 22 (9.6) | 61 (26.8) | 0.518 |
| <65 | 83 (36.4) | 44 (19.3) | 71 (31.3) | 32 (14.0) | 113 (49.6) | ||
| >=65 | 145 (63.6) | ||||||
| Gender | |||||||
| Genotyped | 228 (100) | 101 (44.3) | 106 (46.5) | 0.500 | 50 (21.9) | 157 (68.9) | 0.789 |
| Male | 207 (90.8) | 12 (5.3) | 9 (3.9) | 4 (1.8) | 17 (7.5) | ||
| Female | 21 (9.2) | ||||||
| Smoking (pack-years) | |||||||
| Genotyped | 228 (100) | 48 (21.1) | 41 (18.0) | 0.840 | 21 (9.2) | 68 (29.8) | 0.927 |
| Cases | 89 (39.0) | 85.18 (10–165) | 90.30 (15–200) | 88.19 (15–200) | 87.34 (10–180) | ||
| Mean (range) | 87.12 (10–200) | 65 (28.5) | 74 (32.5) | 33 (14.5) | 106 (46.5) | ||
| να | 139 (61.0) | ||||||
| Primary location | |||||||
| Genotyped | 228 (100) | 46 | 54 | 0.343 | 23 | 77 | 1.000 |
| Left lung | 100 (43.9) | 64 | 56 | 28 | 92 | ||
| Right lung | 120 (52.6) | 3 (1.3) | 5 (2.2) | 3 (1.3) | 5 (2.2) | ||
| NA | 8 (3.5) | ||||||
| Histology | 0.958 | ||||||
| Genotyped | 228 (100) | 51 | 60 | 0.572 | 27 | 84 | |
| Squamous | 111 | 52 | 46 | 23 | 75 | ||
| Adenocarcinoma | 98 | 5 | 6 | 3 | 8 | ||
| Large carcinoma | 11 | 5 (2.2) | 3 (1.3) | 1 (0.4) | 7 (3.1) | ||
| NA | 8 (3.5) | ||||||
| Stage | |||||||
| Genotyped | 228 (100) | 27 | 31 | 0.226 | 13 | 45 | 0.754 |
| I | 58 | 30 | 20 | 10 | 40 | ||
| II | 50 | 35 | 34 | 19 | 50 | ||
| III | 69 | 15 | 24 | 8 | 31 | ||
| IV | 39 | 6 (2.6) | 6 (2.6) | 4 (1.8) | 8 (3.5) | ||
| NA | 12 (5.3) | ||||||
| Grade | |||||||
| Genotyped | 228 (100) | 4 | 2 | 0.570 | 0 | 6 | 0.262 |
| I | 6 | 41 | 44 | 23 | 62 | ||
| II | 85 | 48 | 41 | 19 | 70 | ||
| III | 89 | 20 (8.8) | 28 (12.3) | 12 (5.3) | 36 (15.8) | ||
| NA | 48 (21.1) | ||||||
| Maximum diameter (cm) | |||||||
| Genotyped | 228 (100) | 95 | 91 | 0.435 | 44 | 142 | 0.618 |
| Cases (%) | 186 | 5.02 (1.20–14) | 4.68 (0.7–21) | 4.8 (0.7–21) | 4.88 (1.1–14) | ||
| Mean (range) | 4.87 (0.7–21) | 18 (7.9) | 24 (10.5) | 10 (4.4) | 32 (14.0) | ||
| NA | 42 (18.4) | ||||||
| Lymph node infiltration | |||||||
| Genotyped | 228 (100) | 43 | 48 | 0.286 | 25 | 66 | 0.287 |
| No | 91 | 44 | 35 | 16 | 63 | ||
| Yes | 79 | 26 (11.4) | 32 (14.0) | 13 (5.7) | 45 (19.7) | ||
| NA | 58 (25.4) | ||||||
| Metastasis (adrenals)a | |||||||
| Genotyped | 228 (100) | 18 | 17 | 0.384 | 8 | 27 | 0.730 |
| No | 35 | 6 | 10 | 5 | 11 | ||
| Yes | 16 | 89 (39.0) | 88 (38.5) | 41 (18.0) | 136 (59.6) | ||
| NA | 177 (77.6) | ||||||
| Metastasis (liver)a | |||||||
| Genotyped | 228 (100) | ||||||
| No | 30 | 16 | 17 | 1.000 | 8 | 25 | 1.000 |
| Yes | 20 | 9 | 11 | 5 | 15 | ||
| NA | 175 (76.8) | 8 (38.6) | 87 (38.2) | 4 (18.0) | 134 (58.8) | ||
| Metastasis (brain)a | |||||||
| Genotyped | 228 (100) | 19 | 15 | 0.144 | 8 | 26 | 0.784 |
| No | 34 | 12 | 21 | 9 | 24 | ||
| Yes | 33 | 82 (36.0) | 79 (34.6) | 37 (16.2) | 124 (54.4) | ||
| NA | 161 (70.6) | ||||||
| Metastasis (bones) a | |||||||
| Genotyped | 228 (100) | 16 | 13 | 0.087 | 7 | 22 | 0.786 |
| No | 29 | 13 | 26 | 11 | 28 | ||
| Yes | 39 | 84 (36.8) | 76 (33.3) | 36 (15.8) | 124 (54.4) | ||
| NA | 160 (70.2) | ||||||
| Metastasis (adrenals–liver–brain–bones)a | |||||||
| Genotyped | 228 (100) | 10 | 3 | 0.032 | 1 | 12 | 0.283 |
| No | 13 | 30 | 43 | 19 | 54 | ||
| Yes | 73 | ||||||
| NA | |||||||
| Survival (2 years) | |||||||
| Genotyped | 228 (100) | 50 | 55 | 0.687 | 19 | 86 | 0.081 |
| Dead | 105 | 59 | 57 | 33 | 83 | ||
| Alive | 116 | 4 (1.8) | 3 (1.3) | 2 (0.9) | 5 (2.2) | ||
| NA | 7 (3.1) | ||||||
| Survival (3 years) | |||||||
| Genotyped | 228 (100) | 60 | 74 | 0.166 | 25 | 109 | 0.033 |
| Dead | 134 | 46 | 38 | 27 | 57 | ||
| Alive | 84 | 7 (3.1) | 3 (1.3) | 2 (0.9) | 8 (3.5) | ||
| NA | 10 (4.4) | ||||||
| Survival (5 years) | |||||||
| Genotyped | 228 (100) | 72 | 84 | 0.294 | 33 | 123 | 0.160 |
| Dead | 156 | 34 | 28 | 19 | 43 | ||
| Alive | 62 | 7 (3.1) | 3 (1.3) | 2 (0.9) | 8 (3.5) | ||
| NA | 10 (4.4) | ||||||
NA, data not available or unknown.
a
Metastasis detected at follow-up, not at the time of sample collection.