Table 9.
ORs and 95% CIs for NSCLC in relation to genotypes of studied SNPs.
| Genotype | Cases n (%) | Controls n (%) | pa | bCrude OR (95% CI) | p | cAdjusted OR (95% CI) | p |
|---|---|---|---|---|---|---|---|
| Total | 229 | 299 | – | – | – | – | – |
| CD40 rs1883832 (T>C) | 228 | 299 | – | – | – | – | – |
| TT | 54 (23.7) | 73 (24.4) | 0.003 | 1.414 (0.911–2.196) | 0.122 | 1.508 (0.930–2.445) | 0.096 |
| CT | 61 (26.8) | 118 (39.5) | 2.024 (1.348–3.039) | 0.001 | 1.865 (1.192–2.919) | 0.006 | |
| CC | 113 (49.5) | 108 (36.1) | 1.000 | - | 1.000 | – | |
| TT+CT | 115 (50.4) | 191 (63.9) | 0.002 | 1.738 (1.224–2.468) | 0.002 | 1.701 (1.154–2.506) | 0.007 |
| vs. CC | 113 (49.6) | 108 (36.1) | |||||
| TT | 54 (23.7) | 73 (24.4) | 0.846 | 1.041 (0.695–1.558) | 0.846 | 1.156 (0.742–1.800) | 0.523 |
| vs. CT+CC | 174 (76.3) | 226 (75.6) | |||||
| CT | 61 (26.8) | 118 (39.5) | 0.002 | 1.785 (1.228–2.594) | 0.002 | 1.606 (1.065–2.422) | 0.024 |
| vs. TT+ CC | 167 (73.2) | 181 (60.5) | |||||
| T allele | 169 (37.1) | 264 (44.1) | 0.021 | 1.342 (1.046–1.722) | 0.021 | 1.384 (1.052–1.821) | 0.020 |
| C allele | 287 (62.9) | 334 (55.9) | 0.745 (0.581–0.956) | 0.021 | 0.723 (0.549–0.951) | 0.020 | |
| BAFFR rs7290134 (A>G) | 229 | 298 | – | – | – | – | – |
| AA | 147 (64.2) | 186 (62.4) | 0.640 | 1.000 | – | 1.000 | – |
| AG | 73 (31.9) | 95 (31.9) | 1.029 (0.708–1.495) | 0.883 | 1.054 (0.697–1.593)0 | 0.803 | |
| GG | 9 (3.9) | 17 (5.7) | 1.493 (0.647–3.446) | 0.348 | 1.647 (0.669–4.056) | 0.278 | |
| AA vs | 147 (64.2) | 186 (62.4) | 0.675 | 0.926 (0.648–1.325) | 0.675 | 0.894 (0.603–1.326) | 0.578 |
| AG+GG | 82 (35.8) | 112 (37.6) | |||||
| AA+AG | 220 (96.1) | 281 (94.3) | 0.351 | 0.676 (0.296–1.546) | 0.354 | 0.666 (0.271–1.637) | 0.376 |
| vs. GG | 9 (3.9) | 17 (5.7) | |||||
| AG vs. | 73 (31.9) | 96 (32.1) | 0.955 | 1.011 (0.699–1.462) | 0.955 | 1.039 (0.691–1.561) | 0.854 |
| AA+GG | 156 (68.1) | 203 (67.9) | |||||
| A allele | 367 (80.1) | 467 (78.4) | 0.482 | 0.898 (0.664–1.213) | 0.482 | 0.864 (0.621–1.202) | 0.385 |
| G allele | 91 (19.9) | 129 (21.6) | 1.114 (0.492–0.929) | 0.482 | 1.158 (0.832–1.611) | 0.385 | |
| LTβR rs10849448 (A>G) | 223 | 299 | – | – | – | – | – |
| AA | 24 (10.8) | 55 (18.4) | 0.054 | 1.894 (1.115–3.217) | 0.018 | 2.051 (1.159–3.628) | 0.014 |
| AG | 61 (27.4) | 77 (25.8) | 1.043 (0.696–1.563) | 0.838 | 0.934 (0.593–1.473) | 0.934 | |
| GG | 138 (61.8) | 167 (55.8) | 1.000 | – | 1.000 | – | |
| AA vs | 24 (10.8) | 55 (18.4) | 0.016 | 1.869 (1.117–3.127) | 0.017 | 2.106 (1.210–3.667) | 0.008 |
| AG+GG | 199 (89.2) | 244 (81.6) | |||||
| AA+AG vs | 85 (38.1) | 132 (44.1) | 0.167 | 0.779 (0.547–1.110) | 0.167 | 1.255 (0.848–1.856) | 0.256 |
| GG | 138 (61.9) | 167 (55.9) | |||||
| AG | 61 (27.4) | 77 (25.8) | 0.681 | 0.921 (0.622–1.364) | 0.681 | 0.995 (0.978–1.013) | 0.602 |
| vs, GG+AA | 162 (72.6) | 222 (74.2) | |||||
| A allele | 109 (24.4) | 187 (31.3) | 0.015 | 1.407 (1.067–1.855) | 0.016 | 1.436 (1.060–1.945) | 0.019 |
| G allele | 337 (75.6) | 411 (68.7) | 0.711 (0.539–0.937) | 0.016 | 0.696 (0.514–0.943) | 0.019 |
ap derives from the χ2 test and refers to the overall association of genotypes with NSCLC risk. bp, OR, and 95% CI derived from logistic regression analysis using no cofactor. cp, OR, and 95% CI derived from logistic regression analysis using age and gender as cofactors.
CI, confidence interval; OR, odds ratio.
Bold text indicates a statistically significant correlation with a p-value less than 0.05.