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. 2021 Sep 17;11:682928. doi: 10.3389/fonc.2021.682928

Table 2.

Univariate Analysis of risk factors for tumor recurrence and long-term survival in patients with PDAC.

Index Variables (Number) OS (Moths) Index Variables (Number) DFS (Moths)
Mean 95%CI P value (U) Mean 95%CI P value (U)
NLR >2.9 (118) 16.030 12.149-19.912 0.000 NLR >2.9 (118) 14.116 10.191-18.042 0.000
≤2.9 (123) 36.574 30.763-42.385 67.869 ≤2.9 (123) 34.196 27.989-40.402 61.696
Age >55 (185) 24.247 20.038-28.456 0.032 Age >55 (185) 21.087 17.058-26.105 0.039
≤55 (56) 33.689 24.385-42.992 4.662 ≤55 (56) 32.156 22.300-42.013 4.257
PBD Yes(23) 15.957 9.268-22.627 0.044 PBD Yes(23) 13.304 6.566-20.053 0.041
No (218) 27.088 22.919-31.258 4.064 No (218) 25.104 20.622-29.547 4.179
CA-199 >37 (137) 21.735 17.426-26.044 0.038 CA-199 >37 (137) 19.041 14.585-23.497 0.031
≤37 (104) 32.587 25.769-39.404 4.291 ≤37 (104) 31.050 23.895-38.205 4.639
TNM >II b (91) 14.368 11.332-17.405 0.000 TNM >II b (91) 12.248 9.007-15.488 0.000
≤II b (150) 32.431 27.075-37.787 26.988 ≤II b (150) 30.427 24.740-36.113 24.185
Tumor Size >4 (72) 19.284 13.882-24.687 0.002 Tumor Size >4 (72) 17.648 12.080-23.216 0.003
≤4 (169) 28.526 23.927-33.126 9.627 ≤4 (169) 26.286 21.418-31.153 8.600
Tumor differentiation I (31) 15.782 9.902-21.663 0.012 Tumor differentiation I (31) 13.660 7.416-119.905 0.015
II (56) 21.715 14.656-28.775 II (56) 20.455 13.172-27.738
III (126) 28.928 23.525-34.342 10.883 III (126) 26.658 20.918-32.397 10.552
VI (28) 25.982 16.998-34.966 VI (28) 23.969 14.171-33.767
Vascular anastomosis I (11) 9.909 4.403-15.415 0.042 Vascular anastomosis I (11) 7.727 2.206-13.249 0.056
II (146) 26.997 21.998-31.996 II (146) 24.984 19.658-30.310
III (26) 30.154 17.696-42.616 8.224 III (26) 27.192 14.788-39.596 7.549
IV(58) 22.212 16.444-27.979 IV(58) 19.932 13.734-26.131
Operation Methods I (11) 9.909 4.403-15.415 0.001 Operation Methods I (11) 7.727 2.206-13.249 0.004
II (160) 28.484 23.566-33.402 II (160) 26.461 21.241-31.681
III (21) 11.333 8.608-14.059 17.073 III (21) 9.122 6.601-11.643 13.563
IV (49) 26.952 18.133-35.772 IV (49) 25.142 15.821-34.463
Incisal Margin R0 (227) 27.153 23.111-31.195 0.000 Incisal Margin R0 (227) 25.155 20.853-29.457 0.000
R1(14) 8.929 4.460-13.397 14.909 R1(14) 6.857 2.395-11.319 12.684
Lymphatic metastasis Negative (83) 37.618 29.653-45.582 0.000 Lymphatic metastasis Negative (83) 36.558 28.178-44.937 0.000
Positive (158) 19.878 16.454-23.301 14.786 Positive (158) 16.993 13.540-20.446 15.328
Vascular invasion I (11) 9.909 4.403-15.415 0.007 Vascular invasion I (11) 7.727 2.206-13.249 0.012
II (146) 28.543 23.386-33.700 9.966 II (146) 26.260 20.744-31.745 8.852
III (84) 21.510 16.696-26.325 III (84) 19.644 14.494-24.794

NLR, Neutrophil To Lymphocyte Ratio; PBD, preoperative biliary drainage; Tumor differentiation I: poorly, II: poorly-moderately, III: moderately, VI: moderately-highly; Vascular anastomosis I: palliative operation, II: partially excised and sutured directly, III end-to-end anastomosis, VI allogeneic vascular replacement; Operation Methods I: palliative operation, II: radical pancreaticoduodenectomy, III: total pancreatectomy, VI: distal pancreatectomy; Vascular invasion I: palliative operation, II: Chaoyang type I, III: Beyond Chaoyang type I.