Table 1.
Description of Infection Healthcare Personnel
| Participant No. |
Age | Sex | Symptoms | SARS-CoV-2 Cycle Threshold | Vaccine Status | Time From Second Dose (Days) |
No. of Positive Contacts | Serology Within 3 Days of Diagnosis AU/mLa |
Serology Within 3 Days of Diagnosis BAU/mL |
Serology After at Least 12 Days of Diagnosis AU/mLa |
Serology After at Least 12 Days of Diagnosis BAU/mL |
NGS Findings |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 26 | Female | Mild | 16 | Unvaccinated | NA | NA | |||||
| 2 | 31 | Female | Mild | 15 | Unvaccinated | NA | NA | |||||
| 3 | 32 | Male | Asymptomatic | 16 | Unvaccinated | NA | NA | |||||
| 4 | 46 | Female | Mild | 27 | Unvaccinated | NA | Anti-S negative Anti-N negative |
B.1.1.7/501.v1 | ||||
| 5 | 24 | Female | Mild | 15 | Partially vaccinated | NA | NA | |||||
| 6 | 67 | Female | Mild | 20.5 | Partially vaccinated | NA | Anti-S positive, 1554 Anti-N negative |
Anti-S positive, 221 | B.1.1.7/501.v1 | |||
| 7 | 32 | Female | Asymptomatic | 17 | Partially vaccinated | 4 | 0/2 | Anti-S positive, 14260 Anti-N negative |
Anti-S positive, 2025 | B.1.1.7/501.v1 | ||
| 8 | 67 | Female | Asymptomatic | 23 | Fully vaccinated | 9 | 0/0 | Anti-S -positive, 11190 Anti-N negative |
Anti-S positive, 1589 | Anti-S positive, 6808 Anti-N positive |
Anti-S positive, 967 | B.1.1.7/501.v1 |
| 9 | 58 | Female | Mild | 22 | Fully vaccinated | 11 | 0/7 Only 6 tested | Anti-S positive, 965 Anti-N negative |
Anti-S positive, 137 | Anti-S positive, 13045 Anti-N negative |
Anti-S positive, 1852 | B.1.1.7/501.v1 |
| 10 | 49 | Male | Asymptomatic | 31 | Fully vaccinated | 16 | 0/3 Not tested |
Anti-S positive, 12479 Anti-N negative |
Anti-S positive, 1772 | |||
| 11 | 38 | Female | Asymptomatic | 23 | Fully vaccinated | 14 | 0/4 Only 1 tested |
Anti-S positive, 4653 Anti-N negative |
Anti-S positive, 661 | Anti-S positive, 6223 Anti-N positive |
Anti-S positive, 884 | |
| 12 | 66 | Female | Mild | 20 | Fully vaccinated | 20 | 0/6 | NA | Anti-S positive, 21947 Anti-N positive |
Anti-S positive, 3116 | ||
| 13 | 60 | Female | Mild | 29 | Fully vaccinated | 20 | 0/2 Not tested |
NA | Anti-S positive, 24616 Anti-N positive |
Anti-S positive, 3495 | B.1.1.7/501.v1 | |
| 14 | 54 | Female | Asymptomatic | 36 | Fully vaccinated | 14 | 1/1 | NA | ||||
| 15 | 41 | Male | Asymptomatic | 19 | Fully vaccinated | 10 | 0/4 Not tested |
NA | B.1.1.7/501.v1* |
Note. AU/mL; arbitrary units per milliliter; BAU/mL, WHO binding antibody units; NA, not available. NGS, next-generation sequencing
IgG II Quant assay are reported in AU/mL. A conversion factor between AU/mL and BAU/mL has been established as 1 BAU = 0.142 AU. Additional SARS-CoV-2 positive RNA of a seventh employee was also characterized as the same variant based on receptor-binding domain (RBD) sequencing alone without performing whole-genome sequencing (data not shown in the main text)