Table 3.

Cox proportional hazards model for non-cancer mortality.

Variable	Univariable		Multivariable model 1*		Multivariable model 2*
	HR (95% CI)	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value
Age (years)	1.11 (1.02-1.21)	0.03	–	–	–	–
Age-adjusted CCI score, continuous	3.30 (1.66-6.55)	0.001	2.94 (1.47-5.89)	0.002	3.06 (1.52-6.15)	0.002
NCCN risk groups
High	Reference
Very high	1.77 (0.58-5.41)	0.32
BMI at baseline (1 kg/m2 increase)	0.95 (0.81-1.10)	0.47
BMI change (per 1%/180 days increase)	0.91 (0.80-1.02)	0.12
SMI at baseline (1 cm2/m2 decrease)	1.04 (0.96-1.12)	0.32
Sarcopenia at baseline	1.35 (0.44-4.13)	0.60
SMI change (per 1%/180 days decrease)	1.09 (1.04-1.15)	0.001	1.09 (1.02-1.16)	0.007	–	–
SMI loss ≥5% (Reference: SMI maintain)	6.95 (1.54-31.39)	0.01	–	–	5.60 (1.23-25.45)	0.03
SMD at baseline (1 HU decrease)	1.08 (0.98-1.19)	0.10
SMD change (per 1%/180 days decrease)	1.05 (0.99-1.11)	0.09
SATI at baseline (1 cm2/m2 increase)	1.01 (0.97-1.05)	0.70
SATI change (per 1%/180 days increase)	0.99 (0.96-1.02)	0.42
VATI at baseline (1 cm2/m2 increase)	1.00 (0.98-1.02)	0.66
VATI change (per 1%/180 days increase)	0.99 (0.97-1.02)	0.51
TATI at baseline (1 cm2/m2 increase)	1.00 (0.98-1.01)	0.85
TATI change (per 1%/180 days increase)	1.01 (0.98-1.04)	0.48	1.03 (0.99-1.07)	0.10	–	–

BMI, body mass index; CI, confidence interval; CCI, Charlson Comorbidity Index; CT, computed tomography; HR, hazard ratio; HU, Hounsfield unit; IQR, interquartile range; NCCN, National Comprehensive Cancer Network; SMD, skeletal muscle radiodensity; SMI, skeletal muscle index; SATI, subcutaneous adipose tissue index; TATI, total adipose tissue index; VATI, visceral adipose tissue index.

Data are mean ± standard error or number (%).

*Multivariable analysis using a backward selection method.