Table 1.
Functional classification of the methylated genes using Genomatix software.
| Functional categories | GO term ID | p value | List of genes |
|---|---|---|---|
| Calcium channel activity | GO:0005262 | 1.12E − 03 | CACNA1H, CACNA1C, CACNA2D4, TRPM3, JPH3 |
| Dolichyl-phosphate-mannose-protein mannosyltransferase activity | GO:0004169 | 1.37E − 03 | TMTC4, POMT2 |
| Enzyme binding | GO:0019899 | 2.56E − 03 | SLC9A3R2, ATP6V0A4, EXOC2, FRS2, EZR, CARHSP1, STXBP5, PHACTR1, CNST, RALGPS2, SH3BP4, AURKA, SMYD3, PRKN, SLC2A1, DENND3, RASGEF1A, JAKMIP3, MARCHF6, HDAC4, SYNE1, ARFGEF3, PSD3, MCF2L, GATA4 |
| Coreceptor activity | GO:0015026 | 2.83E − 03 | GPC6, CD80, RGMA |
| ATP-dependent microtubule motor activity | GO:1990939 | 3.41E − 03 | KIF26A, DNAH2, KIF17 |
| Isomerase activity | GO:0016853 | 4.29E − 03 | TXNDC5, NAXD, QSOX1, TOP1MT, PDIA6 |
| Ubiquitin-specific protease binding | GO:1990381 | 5.61E − 03 | PRKN, MARCHF6 |
| Tubulin binding | GO:0015631 | 5.95E − 03 | KIF26A, EZR, CCDC88B, TBCD, PRKN, JAKMIP3, KIF17 |
| Oxidoreductase activity, acting on a sulfur group of donors | GO:0016667 | 6.09E − 03 | QSOX1, PDIA6, NXN |
| ARF guanyl-nucleotide exchange factor activity | GO:0005086 | 6.25E − 03 | ARFGEF3, PSD3 |
| GTPase binding | GO:0051020 | 7.52E − 03 | EXOC2, STXBP5, RALGPS2, SH3BP4, DENND3, RASGEF1A, ARFGEF3, PSD3, MCF2L |
| Protein binding | GO:0005515 | 8.37E − 03 | TRIM2, CACNA1H, SPSB1, KIF26A, SLC9A3R2, ESPNL, AUTS2, TXNDC5, CACNA1C, TCAF2, ZFYVE28, SPON2, ATP6V0A4, MAD1L1, EXOC2, FRS2, DPF3, ERGIC1, SPATA18, CUX1, EZR, COLEC11, RPA3, GPC6, AHRR, MFAP3L, CARHSP1, DNAH2, ZNRF4, PFKP, BANP, CCDC88B, SCN8A, STXBP5, PHACTR1, CNST, RALGPS2, NAXD, TBCD, PRKG1, JMJD1C, USP10, LRTM2, ST8SIA5, CCDC60, DLGAP2, SH3BP4, AURKA, TG, LTBP2, SMYD3, PRKN, COL4A2, SLC2A1, IGHMBP2, DENND3, SDHA, HMGB4, CHFR, MPHOSPH10, SNTG2, RASGEF1A, JAKMIP3, PDIA6, PHLDB2, MARCHF6, FRK, HDAC4, TBL3, TLE1, SYNE1, ARFGEF3, PSD3, KIF17, ZNF239, FOXP4, MCF2L, FSTL4, ANO2, SOX6, GATA4, AGPAT4, CD80, SPPL2B, TERT, DAB1, RGMA |
| Passive transmembrane transporter activity | GO:0022803 | 8.64E − 03 | CACNA1H, CACNA1C, CLCN7, CACNA2D4, SCN8A, TRPM3, JPH3, ANO2 |
| Cytoskeletal protein binding | GO:0008092 | 8.66E − 03 | KIF26A, ESPNL, CACNA1C, EZR, CCDC88B, STXBP5, PHACTR1, TBCD, PRKN, SNTG2, JAKMIP3, SYNE1, KIF17 |