Table 1.
Characteristics of Participants Included in the Current Studya From Clinical Practice Research Datalink, Hospital Episode Statistics, and the Office for National Statistics, England, United Kingdom, 2004–2017
| Characteristic | Men | Women | ||||
|---|---|---|---|---|---|---|
| No. of Individuals With at Least 1 Measurement | Mean (SD) | % | No. of Individuals With at Least 1 Measurement | Mean (SD) | % | |
| Derivation data set | 518,367 | 622,731 | ||||
| Age at study entry, years | 518,367 | 50.3 (12.6) | 622,731 | 51.3 (13.5) | ||
| Systolic blood pressure, mm Hgb | 484,714 | 136.9 (18.5) | 603,496 | 131.7 (20.4) | ||
| Total cholesterol, mmol/Lb | 374,492 | 5.4 (1.0) | 437,519 | 5.6 (1.1) | ||
| HDL cholesterol, mmol/Lb | 348,176 | 1.3 (0.4) | 405,960 | 1.6 (0.4) | ||
| Current/ever smokerc | 306,719 | 48.6 | 295,502 | 47.3 | ||
| History of diabetesc | 518,367 | 7.1 | 622,731 | 4.9 | ||
| Prescription for antihypertensive medicationc | 518,367 | 35.1 | 622,731 | 38.8 | ||
| Initiated statins after study entry | 518,367 | 16.2 | 622,731 | 12.6 | ||
| Experienced incident CVD event | 518,367 | 7.4 | 622,731 | 5.2 | ||
| Validation data set | 244,239 | 293,390 | ||||
| Age at study entry, years | 244,239 | 50.5 (12.6) | 293,390 | 51.5 (13.5) | ||
| Systolic blood pressure, mm Hg | 229,861 | 136.2 (18.4) | 285,603 | 131.2 (20.3) | ||
| Total cholesterol, mmol/L | 174,843 | 5.4 (1.1) | 203,461 | 5.6 (1.1) | ||
| HDL cholesterol, mmol/L | 159,466 | 1.3 (0.4) | 184,901 | 1.6 (0.4) | ||
| Current/ever smoker | 144,130 | 47.9 | 139,896 | 45.9 | ||
| History of diabetes | 244,239 | 6.9 | 293,390 | 4.8 | ||
| Prescription for antihypertensive medication | 244,239 | 34.9 | 293,390 | 38.8 | ||
| Initiated statins after study entry | 244,239 | 16.0 | 293,390 | 12.5 | ||
| Experienced incident CVD event | 244,239 | 7.2 | 293,390 | 5.1 | ||
Abbreviations: CVD, cardiovascular disease; HDL, high-density lipoprotein; SD, standard deviation.
a Included 1,678,727 individuals aged 40–85 years, without prevalent CVD or statin initiation at study entry, and with at least 1 measurement value of systolic blood pressure, total cholesterol, HDL cholesterol, or smoking status between their study entry and study exit dates.
b Calculated using the first measurement values taken after study entry.
c Recorded as “yes” if any of the measurement values showed “yes” throughout the follow-up time.