Table 4.

Ten-Year Cardiovascular Disease Risk Classification Comparing Statin-Naive Risk Predictions Versus Standard Risk Predictions for Women in the Validation Data Set (in Landmark Ages at 40, 50, 60, and 70 Years^a), Clinical Practice Research Datalink, Hospital Episode Statistics, and the Office for National Statistics, England, United Kingdom, 2004–2017

Standard 10-Year CVD Risk Predictions	Statin-Naive 10-Year CVD Risk Predictions
	<10%	≥10%	Total
Landmark Age 40 Years
Events within 10 yearsb
<10%	329	0	329
≥10%	0	8	8
Subtotal	329	8	337
Event-free at 10 years
<10%	3,759	3	3,762
≥10%	0	6	6
Subtotal	3,759	9	3,768
Landmark Age 50 Years
Events within 10 years
<10%	723	10	733
≥10%	0	59	59
Subtotal	723	69	792
Event-free at 10 years
<10%	3,073	10	3,083
≥10%	0	43	43
Subtotal	3,073	53	3,126
Landmark Age 60 Years
Events within 10 years
<10%	948	54	1,002
≥10%	0	277	277
Subtotal	948	331	1,279
Event-free at 10 years
<10%	2,180	82	2,262
≥10%	0	226	226
Subtotal	2,180	308	2,488
Landmark Age 70 Years
Events within 10 years
<10%	19	8	27
≥10%	0	1,634	1,634
Subtotal	19	1,642	1,661
Event-free at 10 years
<10%	7	2	9
≥10%	0	1,084	1,084
Subtotal	7	1,086	1,093

Abbreviation: CVD, cardiovascular disease.

^a The results are presented in 10-year increments in landmark age at 40, 50, 60, and 70. Above landmark age 76 for women, the predicted 10-year CVD risk for all individuals in the risk set was greater than 10% for both standard risk predictions and statin-naive risk predictions; therefore, there was no movement between the 2 categories for those older landmark age groups.

^b Events within 10 years and event-free at 10 years for the reclassification table were defined using the counterfactual follow-up time, assuming statin had not been initiated.