Table 4.
Multivariate analysis of factors associated with nonadherence.
Characteristics | Odds ratio (95% CI) | P value | ||||
Diagnosis year (per year) | 0.88 (0.81-0.94) | <.001 | ||||
Age (years) | <.001 | |||||
|
50-70 vs ≤50 | 1.08 (0.88-1.31) | .45 | |||
|
>70 vs ≤50 | 2.85 (2.19-3.70) | <.001 | |||
Educational level (high school or higher vs middle school or lower) | 0.76 (0.64-0.91) | .002 | ||||
Menopausal status (post vs pre) | 1.01 (0.72-1.41) | .96 | ||||
Family history of breast cancer (yes vs no) | 0.70 (0.48-1.00) | .05 | ||||
Axillary surgery (ALNDa vs SLNBb) | 0.72 (0.55-0.96) | .03 | ||||
Tumor size (>2 cm vs ≤2 cm) | 0.83 (0.62-1.09) | .18 | ||||
Lymph node status (positive vs negative) | 1.40 (1.04-1.88) | .03 | ||||
Pathological subtype (Non-IDCc vs IDC) | 0.77 (0.58-1.02) | .07 | ||||
Tumor grade | .15 | |||||
|
III versus I or II | 1.19 (0.97-1.45) | .10 | |||
|
Unknown versus I or II | 1.36 (0.84-2.20) | .21 | |||
PRd status (positive vs negative) | 0.86 (0.66-1.12) | .28 | ||||
HER2e status (positive vs negative) | 2.04 (1.34-3.10) | .001 | ||||
Ki-67 index (≥14% vs <14%) | 0.96 (0.73-1.26) | .75 | ||||
Molecular subtype | <.001 | |||||
|
Luminal-B like (HER2 negative) versus Luminal-A like | 1.83 (1.29-2.59) | .001 | |||
|
Luminal-B like (HER2 positive) versus Luminal-A like | 1.60 (1.16-2.21) | .005 | |||
|
HER2 positive versus Luminal-A like | N/Af | N/A | |||
|
Triple negative versus Luminal-A like | 2.11 (1.41-3.14) | <.001 | |||
TNMg stage | .02 | |||||
|
Stage II versus stage I | 1.35 (1.08-1.69) | .008 | |||
|
Stage III versus stage I | 1.57 (1.09-2.25) | .01 | |||
Group according to app use | .02 | |||||
|
App nonused cohort versus Pre-App cohort | 0.96 (0.70-1.29) | .77 | |||
|
App used cohort versus Pre-App cohort | 0.61 (0.43-0.87) | .007 |
aALND: axillary lymph node dissection.
bSLNB: sentinel lymph node biopsy.
cIDC: invasive ductal carcinoma.
dPR: progesterone receptor.
eHER2: human epidermal growth factor receptor 2.
fN/A: not applicable.
gTNM: tumor, lymph node, and metastasis.