Table 3.

Published studies of adipose-derived stem cell derived exosome in ischaemic stroke

Animals	Stroke model	Time of treatment	Routes of exosome delivery	Exosome modifications	Proposed mechanisms	Ref
Rat	50 min tMCAO	3 hours after ischaemia	Intravenously	No	Anti-inflammation, anti-apoptosis	155
Rat	tMCAO	Immediately after ischaemia	Tail vein	Enriched with miR-30d-5p	Reduce autophagy and inflammation, and promote microglia M2 polarisation	105
Rat	tMCAO	Not mentioned	Intravenously	Enriched with miR-126	Promote neurogenesis, angiogenesis, anti-inflammation	104
Rat	1 hour tMCAO	3 days before ischaemia	Lateral cerebral ventricle injection	Loaded with pigment epithelium-derived factor	Promote autophagy	156

tMCAO, transient middle cerebral artery occlusion.